孟鲁司特钠联合特布他林雾化吸入治疗儿童咳嗽变异性哮喘伴肺炎支原体感染的疗效观察

摘要

OBJECTIVE:To probe into the efficacy ofmontelukast sodium combined with terbutaline atomization inhalation in treatment of children with cough variant asthma and mycoplasma pneumoniae infection.METHODS:92 children with cough variant asthma and mycoplasma pneumoniae infection admitted into Jingdezhen Maternal and Child Health Hospital from Nov.2015 to Nov.2016 were according to admission order grouping,single number as the group A,double number as the group B,with 46 cases in each.Group A was treated with terbutaline atomization inhalation,while group B additionally received montelukast sodium based on group A.The clinical efficacy of two groups were observed,differences of PEF％,FEV1 and FEV1/FVC of two groups were compared before and after treatment.RESULTS:After treatment,the PEF％,FEV1 and FEV1/FVC of group B were significantly higher than those of group A,with statistically significant difference(P<0.05).The total effective rate of group B was 95.65％(44/46),significantly higher than that of group A [82.61％(38/46)],with statistically significant difference(P<0.05).CONCLUSIONS:The efficacy of montelukast sodium combined with terbutaline atomization inhalation in treatment of children with cough variant asthma and mycoplasma pneumoniae infection is remarkable.%目的:探讨孟鲁司特钠联合特布他林雾化吸入治疗儿童咳嗽变异性哮喘伴肺炎支原体感染的疗效.方法:选取2015年11月-2016年11月景德镇市妇幼保健院收治的咳嗽变异性哮喘伴肺炎支原体感染患儿92例作为研究对象,按照入院顺序分组,单号为A组,双号为B组,每组46例.A组患儿给予特布他林雾化吸入治疗,B组患儿在A组的基础上加用孟鲁司特钠治疗.观察两组患儿的临床疗效,比较两组患儿治疗前后的最大呼气流量占正常预计值的百分比(PEF％)、1 s用力呼气容积(FEV1)、1 s用力呼气容积占用力肺活量百分比(FEV1/FVC)的差异.结果:治疗后,B组患儿的PEF％、FEV1、FEV1/FVC明显高于A组,差异均有统计学意义(P<0.05);B组患儿的总有效率为95.65％(44/46),明显高于A组的82.61％(38/46),差异有统计学意义(P<0.05).结论:孟鲁司特钠联合特布他林治疗儿童咳嗽变异性哮喘伴肺炎支原体感染的疗效显著.