喜炎平注射液治疗儿童非肠道病毒71型疱疹性咽峡炎的疗效及安全性

摘要

OBJECTIVE:To probe into the efficacy and safety of Xiyanping injections in treatment of non EV 71 herpangina in children .METHODS:115 children with non EV71 herpangina were selected to be divided into three groups via the random number table .38 cases in group A were given Xiyanping injections , 40 cases in group B were treated with Xiyanping combined with ribavirin injections , and 37 cases in group C received ribavirin injections .The improvement of clinical symptoms and laboratory indicators of three groups were compared . RESULTS: After treatment, the disappearance time of fever time and herpes , and recovery time of feeding in group A and B were shorter than those in control group , with statistically significant difference ( P <0.05 ) , yet the difference was not statistically significant between group A and B ( P>0.05 ) .The CPR level of group A and B was significantly lower than that of control group in the 3 rd day after treatment , with statistically significant difference ( P<0.05 ) , yet the difference was not statistically significant between group A and B ( P>0.05) .During the treatment , no serious adverse drug reactions were found during the treatment in three groups .CONCLUSIONS:Non EV71 herpangina has the self limiting.The application of Xiyanping injections at the onset of the diseases has a significant clinical efficacy , which can significantly improve patients ' symptoms with high safety .%目的:探讨喜炎平注射液治疗儿童非肠道病毒71(EV71)型疱疹性咽峡炎的疗效及安全性.方法:选择115例非EV71型疱疹性咽峡炎患儿作为研究对象,按随机数字表法分为三组.A组38例患儿给予喜炎平注射液;B组40例患儿给予喜炎平注射液联合利巴韦林注射液;C组37例患儿给予利巴韦林注射液.比较各组患儿临床症状和实验室指标改善情况.结果:治疗后,A、B组患儿发热持续时间、疱疹消退时间及饮食恢复时间明显短于C组,差异均有统计学意义(P<0.05),但A、B组间的差异无统计学意义(P>0.05).治疗第3日,A、B组患儿的C反应蛋白水平明显低于C组,差异均有统计学意义(P<0.05),但A、B组间的差异无统计学意义(P>0.05).三组患儿在治疗期间及治疗后均未见明显不良反应.结论:非EV71型疱疹性咽峡炎有一定自限性,早期及时给予喜炎平注射液治疗,效果较好,可明显改善患者症状,且安全性较高.