Drugs could affect the activity of CYP450 isoenzyme, which would influence drug safety and efficacy of the substrates of CYP450 isoenzyme. Desethylamiodarone, an in vivo metabolite of amiodarone, not only contributes to its therapeutic effect, at the same time, also plays great role in the side effects of amiodarone by influencing the CYP450 isoenzyme system. Therefore, neglecting the influence factors of desethylamiodarone will affect the safety and efficacy evaluation of amiodarone.%药物可通过CYP450同工酶途径影响其底物药物临床使用的安全性和有效性。胺碘酮体内代谢产物去乙基胺碘酮不仅对其治疗作用贡献较大,同时,对CYP450同工酶系的影响也较为广泛,作用也更强。因此,对胺碘酮临床使用的评估,忽视去乙基胺碘酮的影响因素,将影响胺碘酮临床使用的安全性和有效性。
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