Objective Aim To determine the diabetic foot ulcer incidence and examine its association with microangiopathy complications, including diabetic retinopathy (DR) and albuminuria (Alb), in type 2 diabetes patients. Methods This was a retrospective cohort study of 435 patients with type 2 diabetes who were assigned to the following groups: group Ⅰ, nor-moalbuminuria without DR; group Ⅱ, Alb without DR; group Ⅲ, normoalbuminuria with DR; and group Ⅳ, Alb with DR . Cox proportional hazard models were used to compare the risks of developing diabetic foot ulcers across the categories. Re-sults During5 years of follow-up, 20 subjects developed diabetic foot ulcers, with incidence rates of 1.6/1000, 1.5/1000, 3.4/1000, and 12.5/1000 person-years in group Ⅰ、Ⅱ、Ⅲ and Ⅳ, respectively. After adjusting for the presence of diabetic neuropathy and macroangiopathy, the hazard ratios and 95%confidence intervals (CIs) for the risk of diabetic foot ulcer de-velopment were 0.66 (95%CI, 0.18–2.36), 1.72 (95% CI, 0.67–4.42), and 3.17 (95% CI, 1.52–6.61) in groupⅡ、Ⅲ andⅣ, respectively, compared with group Ⅰ. Conclusion The presence of DR and Alb significantly increases the risk of dia-betic foot ulcer development.%目的：评估2型糖尿病患者糖尿病足溃疡发生率,及其与微血管并发症的相关性,包括糖尿病视网膜病变(DR)和蛋白尿( Alb)。方法该为回顾性研究,研究对象是435例2型糖尿病患者,分为Ⅰ组(正常Alb患者)、Ⅱ组(高Alb患者)、Ⅲ组(正常Alb+DR患者)和Ⅳ(高Alb+DR患者)四组。 Cox比例风险模型分析糖尿病足溃疡的危险因素。结果经过5年随访,20例患者发展为糖尿病足溃疡,Ⅰ、Ⅱ、Ⅲ和Ⅳ组的发生率分别是1.6/1000、1.5/1000、3.4/1000和12.5/1000。与Ⅰ组相比,Ⅱ、Ⅲ和Ⅳ组糖尿病足溃疡发展风险的危险比和95%CI分别是0.66(95% CI,0.18–2.36)、1.72(95%CI,0.67–4.42)和3.17(95%CI,1.52–6.61)。结论2型糖尿病患者DR和Alb与糖尿病足溃疡风险显著增加相关。
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