Targeting SARS-CoV-2 main protease for drug discovery

摘要

The unprecedented pandemic of Coronavirus Disease 2019(COVID-19)was first emerged in Wuhan,China and has spread globally due to its high transmissibility and infectivity,which seriously threaten global health.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a specific virus that can cause COVID-19.Currently,more than 45 million cases have been confirmed according to data supplied by Johns Hopkins University,and at least 1.1 million people have died from SARS-CoV-2.Unfortunately,the number of infected cases continues to grow,while no specific drugs or vaccines are available for the treatment of COVID-19.Therefore,specific drugs against SARS-CoV-2 infection,offering efficacy and safety,are urgently needed.