To study the early diagnosis of serum glutathione S-transferase(GST)in ethanol-induced hepatotoxicity in mice.The result showed that the activities of hepatic glutathione peroxidase,glutathione reductase and superoxide dismutase(SOD)were significantly changed in ethanol(5.7 and 11.4g·kg -1 ig)-treated mice.Serum GST activity and hepatic MDA formation were also remarkably increased.However,there were no serum alanine aminotransferase(ALT) and liver pathological changes.In addition,antioxidants sodium ferulate(100mg·kg -1 ig,qd×10) and allimin(10mg·kg -1 ig,qd×10)treatment could reverse the higher activities of serum GST in ethanol(11.4g·kg -1 )-treated mice.These results suggested that serum GST activity is more sensitive than serum ALT in acute ethanol-induced hepatotoxicity.
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