严重急性呼吸综合征(SARS)冠状病毒刺突蛋白基因片段的表达及其初步应用

摘要

SARS virus spike gene fra gment was expressed by Ecoli expr ession systemThe fragment enclose s major neutralization epitope of the virusThe expressed protein wa s purified and an ELISA method was set upBy using the recombinant,tw elve patients’ sera were detected The recombinant SARS coronavirus s pike protein offers an efficient wa y for serological diagnosis and is useful for epidemiological survey and vaccin e