人尿中一种抗菌物质三甲氧苄二氨基嘧啶的分离、纯化和鉴定

摘要

In order to explain the special antibiotic activity of urine, various chromatographic techniques were applied to separate and purify the key component from the healthy male urine. The structure of purified component was identified by mass spectrometry and NMR. The results indicated that the substance separated from the male urine was trimethoprim. This is the first report of trimethoprim separated from urine.