Is obesity a disease?-the evolving concepts, cancer paradox and association with improved cancer immunotherapy efficacy

摘要

Obesity represents a growing health problem in the United States and worldwide,with a prevalence that has doubled since 1980(1).In the United States,70%of adults and 37%of adolescents are overweight or obese.The chronic health implications of obesity make it a public health issue with significant economic ramifications.By promoting an altered whole-body physiology,obesity increases the risk for chronic diseases including diabetes,cardiovascular disease,and cancer(2).