介入治疗结合红藤治疗输卵管梗阻性不孕症的临床分析

摘要

目的：探讨介入再通术联合中药红藤治疗输卵管梗阻性不孕症的临床效果。方法以2009年8月-2012年8月南华大学附二医院门诊和住院部180例输卵管梗阻性不孕患者为研究对象，采用输卵管介入再通术(FTR)，通过导丝和微导管对248条阻塞输卵管进行机械再通，并经微导管直接造影和注入多种药物，设立试验组和对照组各90例，试验组注入中药红藤粉30 g+庆大霉素8万U+α-糜蛋白酶4000 IU+地塞米松10 mg溶入生理盐水10mL；对照组注入庆大霉素8万U+α-糜蛋白酶4000IU+地塞米松10mg溶入生理盐水10mL，随访6～12个月，观察输卵管通畅度。结果试验组输卵管再通成功率94.1%，对照组输卵管再通成功率91.1%，两组再通成功率无统计学差异。术后输卵管再度阻塞率、完全通畅率比较，术后6～12个月试验组输卵管通畅率为90.4%,输卵管堵塞率为4.40%。对照组术后6～12个月输卵管通畅率为60.7%，输卵管堵塞率为10.7%。试验组的输卵管通畅率明显高于对照组，输卵管再度阻塞率、通而不通畅率明显低于对照组。结论输卵管介入再通术再通液配合中药红藤行灌注术治疗输卵管梗阻是治疗输卵管梗阻性不孕症安全、有效、简单、经济的一种微创性治疗方法。%Objective To evaluate the clinical effect of interventional recanalization technique combined traditional Chinese medicine sargentgloryvine stem in the treatment of oviduct infertility obstruction.Methods From August 2009 to August 2012,in FuEr nanhua university hospital outpatient and the inpatient 180 cases of patients with oviduct obstruction were as the research object,Using the fallopian tube interventional recanalization (FTR), through the guide wire and micro catheter to mechanical recanalization of 248 obstructive fallopian tube, and by the micro-catheter angiography and injection of a variety of drugs directly, set up the experimental group and the control group (n = 90), in which 93 cases of interstitial tubal obstruction, 26 cases of tubal isthmus obstruction , 19 cases of tubal periampullary obstruction .Experimental group were injected with Chinese medicine sargentgloryvine stem powder 30g + gentamicin 80000 U +α-chymotrypsin 4000IU + dexamethasone 10mg dissolved in saline 10mL; the control group were injected with gentamicin 80000U +α-chymotrypsin 4000IU + dexamethasone 10mg dissolved in saline 10mL, were followed up for 6 to 12 experimentalgroup was 90.4%, tubal blockage rate of experimental group was 4.40%. The tubal patency rate of control group was 60.7%, tubal blockage rate of control group was 10.7%. Tubal patencymonths, observation of tubal patency.Results The tubal patency rate in experimental group was 94.1%, in control group was 91.1% , two patency rate was no significant difference. After 6-12 months,The rate of oviduct blocking again and completely patency rate comparison, the tubal patency rate of experimental group was obviously higher than that of control group. The rate of oviduct blocking again and the tubal incomplete patency rate significantly lower than the control group.Conclusion Fallopian tube recanalization in intraoperative recanalization liquid with Chinese medicine sargentgloryvine stem line perfusion surgical treatment of fallopian tubal obstructive infertility is a safe, effective, simple, and minimally invasive treatment of fallopian tube obstructive infertility.