Objective To analyze the risk factors for local relapse and distant metastasis in postoperative patients with lung cancer,and then to explore different subgroups of patients that could beneift from adjuvant radiotherapy or chemotherapy. Methods From June 2007 to June 2010, 152 eligible patients were enrolled and clinical pathologic data were recorded. Disease free survival analyses were performed by the Kaplan-Meier method.Multivariate analyses were performed by the Cox regression analyses.Results The follow-up rate was 100%.The median follow-up time was 27 months (range from 6 months to 55 months). Local-relapse free survival rates and distant-metastasis free survival rates at 1 year,2 years and 3 years were 75.6%, 63.9%,58.3%and 87.3%,72.7%,59.8%,respectively. The median relapse time and metastasis time were 10 months and 13 months, respectively. Multivariate analyses showed that carcino-embryonic antigen(CEA) level, T stage and N stage were the independent risk factors for local relapse and CEA level, tumor size and N stage were the independent risk factors for distant metastasis. Conclusion The risk factors for local relapse or distant metastasis in postoperative patients with lung cancer are different in some parts, which indicates that individualized therapy for these patients maybe be necessary.% 目的探讨肺癌术后复发转移与临床病理因素的关系以及它们的差异性。方法收集2007年6月-2010年6月共152例肺癌根治术后患者，记录其相关的临床病理因素及局部复发、远处转移情况，用Kaplan-Meier法计算无复发转移生存率，用Cox模型多因素分析，分析影响局部复发和远处转移的危险因素。结果随访率100%。随访时间为随访6～55个月，中位数27个月。1、2、3年无复发生存率和无远处转移生存率分别为75.6%、63.9%、58.3%和87.3%、72.7%、59.8%，中位复发时间分别为10个月和13个月。多因素分析结果显示术前癌胚抗原升高、T分期、N分期等为影响局部复发的独立危险因素，而术前癌胚抗原升高、肿瘤大小、N分期等为影响远处转移的独立危险因素。结论肺癌术后局部复发和远处转移的相关危险因素，既有相同，也存在差异，为肺癌的个体化治疗提供一定的依据。
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