控制高尿酸血症对糖耐量减低患者糖代谢的影响

摘要

目的探讨控制高尿酸血症对糖耐量减低（IGT）患者糖代谢的影响。方法将40例住院IGT合并高尿酸血症的病人随机分成2组，对照组单纯饮食控制治疗，研究组在单纯饮食控制治疗基础上加用别嘌呤醇降尿酸治疗。以100 g馒头餐试验评估β细胞功能，观察治疗前后变化。结果经积极降尿酸治疗后，研究组HOMA-IR低于对照组，hsCRP低于对照组，两组间差别有统计学意义。结论 IGT合并高尿酸血症的病人积极控制高尿酸血症有利于降低胰岛素抵抗，纠正糖代谢紊乱，其机制可能与减少炎症因子有关。%Objective To explore the effect of controlling of hyperuricemia on HOMA-IR and glucose metabolism. Methods 40 patients of hyperuricemia (HUA)with impaired glucose tolerence(IGT)were divided into study group and controlled group. The levels of glucose, insulin, uricemia, hs-CRP were determined, HOMA-IR were calculated. The controlled group was treated by only mile-controlled;for study group, treatment to reduce uricemia with mile-controlled added allopurinol for 6 months. The 100 g carbohydrate(steamd bread)challeng of insulin releasing test was performed to evaluate B cell function. Results The study group after treatment showed lower levels of FPG、HOMA-IR and hs-CRP(all P<0.05). Conclusion Control of hyperuricemia could reduce insulin resistance, improve B cell function and glucose metabolism.