Rho激酶抑制剂对创伤性脑损伤的保护作用的临床研究

摘要

目的探讨Rho激酶抑制剂对创伤性脑损伤的保护的临床效果。方法选取60例外伤性蛛网膜下隙出血患者，随机分为Rho激酶抑制剂组（简称观察组）和常规治疗组（简称对照组），比较两组临床症状及体征的改善程度及脑血管痉挛的治疗效果。结果观察组在临床症状及体征改善有效率(60%)上明显高于对照组（30%），两组差异具有统计学意义；Rho激酶抑制剂组治疗后(3、5、12 d)双侧大脑中动脉峰值明显低于对照组，两组差异具有统计学意义(P<0.05)。结论 Rho激酶抑制剂能有效改善外伤性蛛网膜下隙出血的临床症状及体征，且能有效预防脑血管痉挛的发生。%Objective To investigate the curative effects of application of Rho-kinase inhibitor therapy on protection of traumatic brain injury. Methods 60 patients of traumatic subarachnoid hemorrhage were randomLy divided into two groups:Rho-kinase inhibitor therapy group (observation group)and conventional therapy group (control group), the improvement of clinical symptoms and signs,therapeutic effect of CVS were compared. Results The improvement of clinical symptoms and sign in observation group (60%) were better than those in control group (30%), there was significant difference(P<0.05);the flow rate of cerebral vasoconstriction in middle cerebral artery were also lower in observation group than in control group (P<0.05). Conclusion Rho-kinase in habiting therapy can significantly alleviate cerebral vasospasm following tSAH.