小剂量阿司匹林对中老年高血压病患者纤溶活性的影响

摘要

Objective To reserch the impact of low-dose aspirin on fibrinolytic activity in patients with essential hypertension based on blood pressure control well. Methods Forty cases of patients with essential hypertension were divided into control group whose non-taking Bayaspirin and treatment group whose taking bayaspirin(ASA, 100 mg, qn) by random number table. At beginning, the blood pressure controlled well and their good blood pressure after four weeks, The antigen content of t-PA(Tissue-Plasminogen Activator) and PAI-1 (Plasminogen Activator nhibitor-1) in the serum whose forty cases of patients with essential hypertension were detected by ELISA to compare the treatment group with the control group. The experimental data was indicated by mean±standard (x±s). Results Forty cases with essential hypertension will be divided into control group and treatment group by random number table. Compared with before treatment, the plasma t-PA level and PAI-1 level were both significantly decreased(P<0.01) in two groups after conventional antihypertensive therapy. Compared to the control group of conventional antihypertensive therapy after eight weeks, the PAI-1 level whose the treatment group with taking aspirin after four weeks was more pronounced decline (P<0.01). The t-PA level was also decreased, but the comparison between control group and treatment group was not significant(P>0.05).At beginning , the blood pressure controlled well and their good blood pressure after four weeks, the plasma t-PA level and PAI-1 level were decile significantly in inter-group of the treatment group or the control group(P<0.01).Conclusion There is endogenous fibrinolysis disturbance in essential hypertension and antihypertensive treatment may improve fibrinolytic activity. Asipirin can be further improved fibrinolytic activity by influencing PAI-1.%　　目的探讨中老年高血压病患者在血压控制(苯磺酸氨氯地平)良好基础上小剂量阿司匹林对其纤溶活性的进一步影响.方法将40例高血压病患者随机分为处理组(治疗后4周加服ASA,100 mg,qn,)和对照组(不加服ASA).采用酶联免疫吸附法(ELISA)测定组织型纤溶酶原激活剂(t-PA)及组织型纤溶酶原抑制剂(PAI-1)的抗原含量,比较组间、组内的差别.结果处理组和对照组组内前后两两进行比较,t-PA和PAI-1抗原含量下降程度,均有统计学意义(P<0.01).与对照组同一时间点比较,处理组在治疗后4周,t-PA抗原含量下降,有统计学意义(P<0.01)；处理组在加服ASA 4周后,t-PA抗原含量虽有下降,但无统计学意义(P>0.05)；PAI-1抗原含量有进一步下降,且有统计学意义(P<0.01).结论高血压病患者存在纤溶及抗纤溶系统的失衡；苯磺酸氨氯地平可改善纤溶功能；阿司匹林通过影响PAI-1来进一步改善纤溶功能.