分析肺癌患者血清和病变组织中VEGF的表达与预告的关系

摘要

目的：研究分析肺癌患者血清和病变组织中VEGF（vascular endothelial growth factor）的表达与预告的关系，寻找治疗肺癌的有效方法。方法回顾性分析广东省广州市番禺区石碁人民医院和广州市番禺区中心医院及广州医科大学附属第一人民医院2011年2月～2013年2月收治的80例患者的临床资料，分别采用酶联免疫吸附方法和免疫组化的方法检测肺癌患者和肺炎性瘤患者血清中以及各个病变组织中的VEGF的不同表达，分析VEGF的不同表达和患者淋巴结转移、肺癌组织类型、临床分期以及年龄、吸烟史等各相关因素的关系。结果血清中VEGF的表达在肺癌患者中为（321.5±72.5）ng/L；而在肺炎性瘤患者中为（141.5±40.1）ng/L，二者相比差异显著，具有统计学意义（P<0.05）。VEGF的表达和患者的年龄、性别、以及吸烟史没有明显关系，但是和患者肿瘤组织的类型、淋巴结的转移以及分化程度密切相关。出现淋巴结转移的患者表达数量（169.8±15.6）明显高于没有出现淋巴转移的患者，差异具有统计学意义（P<0.05）。结论 VEGF即患者血清中血管内皮生长因子的表现和肺癌患者病变组织的病理类型、淋巴结转移以及分化程度等密切相关。VEGF的表达以及变化情况也许可以为提前诊断肺癌疾病提供帮助。%Objective To study the expression of VEGF(vascular endothelial growth factor)in serum of patients with lung cancer and pathological tissues and forecast of the relationship, to find effective methods for the treatment of lung cancer. Methods Retrospective analysis of Panyu District, Guangzhou City, Guangdong Province, People's Hospital of Shiji (author has three units, specifically which hospital, please explain). And Panyu District, Guangzhou City Centre Hospital (please specify the name of the hospital). And clinical data First Affiliated Hospital of Guangzhou Medical University, from February 2011 to February 2013, 80 patients were treated, respectively, using enzyme-linked immunosorbent assay and immunohistochemical method to detect lung cancer tumors and serum of patients with pneumonia VEGF expression in different tissues in various diseases and to analyze the different VEGF expression and lymph node metastasis, all relevant factors in lung cancer type, clinical stage and age, smoking history. Results The expression of VEGF in serum in patients with lung cancer for (321.5±72.5)ng/L;And in patients with pneumonia neoplasm is (141.5±40.1)ng/L, compared the significant difference, statistically significant (P<0.05). The expression of VEGF and the patient's age, sex, and smoking history was not significantly, but the type of tumor tissue and patients, nodal metastasis, and is closely related to the degree of differentiation. Patients appear to express the number of lymph node metastasis (169.8±15.6) was significantly higher in patients with lymph node metastasis does not appear, the difference was statistically significant (P<0.05). Conclusion VEGF is the performance of the vascular endothelial growth factor in serum and tissue pathological type, lymph node metastasis of lung cancer lesions and is closely related to the degree of differentiation. The expression of VEGF and the changes may help early diagnosis of lung disease.