硝苯地平和酚妥拉明及硫酸镁联合治疗妊高症疗效分析

摘要

Objective To investigate the clinical efficacy of release-controlled nifedipine, phentolamine and magnesium sulfate on the treatment of pregnancy-hypertension syndrome. Methods 298 pregnancy-hypertension syndrome cases were divided into the observation group and the control group, each with 149 cases. The control group was treated with magnesium sulfate;and the initial dosage was as follows:20 mL magnesium sulfate+100 mL 5%glucose for intravenous drip of 30 min;The maintenance dosage was as follows:60 mL magnesium sulfate+1,000 mL 5%glucose for intravenous drip of 8 h;The supplement dosage was 10 mL magnesium sulfate for intramuscular injection. The observation group was treated with release-controlled nifedipine (30 mg/d for oral medication) and phentolamine (20 mL+5%glucose for intravenous drip) additionally. The treatment effects and the influence on the pregnancy outcome were observed. Results After treatment, the systolic pressure and diastolic pressure of the patients in observation group were (129.6±8.6)mmHg and (77.5±8.2)mmHg, significantly lower than (144.2±6.8)mmHg and (85.4±7.1)mmHg of the control group. The difference was statistically significant (P<0.05). The rate of cesarean section of the patients in observation group was 27.5%, significantly lower than 56.4%of the control group (P<0.05).The rate of fetal distress, rate of neonatal asphyxia, neonatal mortality rate and rate of postpartum hemorrhage of the patients in observation group were 8.1%, 5.4%, 0%and 12.8%, significantly lower than 18.8%, 16.1%, 8.1%and 30.2%of the control group (P<0.05). Conclusion The combined treatment of release-controlled nifedipine, phentolamine and magnesium sulfate in treatment of pregnancy-hypertension syndrome is safey and effective.%目的：探讨硝苯地平控释片、酚妥拉明、硫酸镁联合治疗妊娠高血压综合症（妊高症）的临床效果。方法将298例妊高症患者随机均分为观察组和对照组（n=149）。对照组给予硫酸镁治疗，初始剂量：硫酸镁20 mL+5%葡萄糖100 mL静滴，30 min滴完；维持剂量：硫酸镁60 mL+5%葡萄糖1000 mL静滴，8 h滴完；补充剂量：硫酸镁10 mL肌注。观察组在此基础上加用硝苯地平控释片（30 mg/d口服）和酚妥拉明（20 mg+5%葡萄糖静滴）治疗。2组疗程均为7 d。观察2组治疗效果及对妊娠结局的影响。结果观察组患者治疗后收缩压、舒张压分别为(129.6±8.6)mmHg、(77.5±8.2)mmHg，明显低于对照组的(144.2±6.8)mmHg、(85.4±7.1)mmHg，差异具有统计学意义(P＜0.05)；观察组患者剖宫产率为27.5%，明显低于对照组的56.4%(P＜0.05)；观察组患者胎儿窘迫率、新生儿窒息率、新生儿死亡率、产后出血率分别为8.1%、5.4%、0%、12.8%，明显低于对照组的18.8%、16.1%、8.1%、30.2%(P＜0.05)。结论硝苯地平控释片、酚妥拉明、硫酸镁联合治疗妊高症安全、有效。