克莫司软膏治疗糜烂型口腔扁平苔藓效果分析

摘要

Objective To discuss the clinical effect of tacrolimus ointment in the treatment of patients with erosion type of oral lichen planus. Methods 80 patients with erosion type of oral lichen planus in department of stomatology in our hospital were selected and divided into observation group and control group, each group had 40 cases. Observation group was given tacrolimus ointment, and control group was given fluocinolone acetonide. The ointment was applid to affected area 2 times a day, the treatment course was 8 weeksThe clinical effect, incidence of adverse reactions and the recurrence rate of two groups were compared. Results The total effect rate of observation group was 90.0%, and 67.5%in the control group, there was significant difference (P<0.05). there were significant differences on incidence of adverse reactions and the recurrence rate between two groups (P<0.05). Conclusion Tacrolimus ointment in the treatment of erosion type of oral lichen planus has a good clinical curative effect with less adverse reactions and lower recurrence rate.%目的：探讨他克莫司软膏治疗糜烂型口腔扁平苔藓的临床效果。方法选择口腔科就诊的糜烂型口腔扁平苔藓患者80例，将其随机分成观察组和对照组，每组40例。观察组给予他克莫司软膏治疗；对照组应用氟轻松软膏治疗；均2次/d涂于患处，疗程均为8周。观察比较两组的临床疗效、不良反应发生率及复发率。结果观察组总有效率为90.0%，对照组为67.5%，两组总有效率比较差异有统计学意义（P＜0.05）。两组不良反应发生率和复发率比较（10.0% vs 30.0%，7.5% vs 17.5%），差异均有统计学意义（均P＜0.05）。结论他克莫司软膏治疗糜烂型口腔扁平苔藓具有良好的临床疗效，不良反应少，复发率低。