Objective To explore the effect of different doses of urokinase on deep venous thrombosis of lower extremity by atheter-directed thrombolysis. Methods Selected 133 case of patients with deep venous thrombosis of lower extremity in our hospital from January 2014 to January 2015 as object, and the patients were divided into small dose group (0.8 million U)according to the dosage of uroki-nase in the treatment of atheter-directed thrombolysis.The efficacy of thrombolysis, the time of thrombolysis and the occur-rence of bleeding among the three groups were compared. Results The difference of daily dose of urokinase, efficacy of thrombol ysis and time of thrombolysis were statistical significance among the three groups (P0.05). The difference of bleeding incidence rate among the three groups was not statistically significant (P>0.05), but the duration of bleeding was the longest and the bleeding degree was the most serious in the high dose group. Conclusion In the treatment of deep venous thrombosis of lower extremity by urokinase atheter-directed thrombolysis, the daily dose of 0.4~0.8 million U is better, with the lower bleeding rate.%目的：探讨经导管直接溶栓治疗下肢深静脉血栓形成时不同的尿激酶的剂量与治疗效果的关系。方法收集我院收治的下肢深静脉血栓形成患者133例，根据经导管直接溶栓治疗中尿激酶的剂量分为小剂量组（＜40万U）、中剂量组（40~80万U）及大剂量组（＞80万U）。比较三组溶栓疗效、溶栓时间及出血发生情况。结果三组每日尿激酶用量、溶栓有效率、溶栓时间相比，差异均有统计学意义（P＜0.05），小剂量组溶栓有效率低于中剂量组、大剂量组（P<0.05），中剂量组与大剂量组溶栓有效率比较（P＞0.05）；三组出血发生率比较（P＞0.05），但大剂量组出血持续时间最长，出血程度最重。结论尿激酶经导管直接溶栓治疗下肢深静脉血栓形成时，每日40～80万U的剂量溶栓疗效较好，且患者出血率低。
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