Objective To study eradicative effect of family member synchronous therapy in children with helicobacter pylori infection. Methods 194 infantile patients with Hp infection confirmed after the examination of l3C-urea breath test, serum anti-Hp antibody or Hp stool antigen assay were divided into therapy group (96 cases) and control group (98 cases) according to admission time and random digit table. The similar examinations were carried out among 433 family members who had close contact with the children. The overall positive rate of Hp infection was 82% (355/433). All of the patients were treated with synchronous eradicative therapy in therapy group, and in control group only the patients were treated with a combined medication therapy (clarithromy-cin + metronidazole +omeprazole) for one week. Eradicative rates of Hp in two groups were compared. Results The eradicative rate of therapy group was 95.8% (92/96) , and in control group was 81.6% (80/98). The difference had statistical significance (χ2 = 9.73, P <0.01). Conclusion There is a remarkable phenomenon of family aggregation in Hp infection. Parents and other family members who have close contact with the children are an important source of Hp infection in children. Treatment of parents and family members is also important in improving the efficacy rate of eradicative therapy and preventing reinfection in children.%目的 研究幽门螺杆菌( helicobacter pylori,Hp)感染儿童及与其密切接触的家庭成员同步治疗时的Hp根除效果.方法 选择2009年6月-2011年6月我院经C13呼气试验、血清Hp抗体或粪便Hp抗原检测等确诊的Hp感染患儿194例,按入院顺序,查随机数字表将患儿随机分为同治组96例与对照组98例.同时检测与其密切接触的家庭成员共433例,其中Hp感染355例(82％).同治组为患儿及其家庭成员同步接受Hp根治治疗,对照组仅患儿接受治疗,均应用克拉霉素+甲硝唑+奥美拉唑三联1周疗法,观察并比较两组患儿的Hp根除率.结果 同治组的患儿Hp根除率为95.8％(92/96),对照组为81.6％(80/98),两组比较差异有显著统计学意义(x2=9.73,P＜0.O1).结论 Hp感染有家庭内聚集现象,父母及与儿童有密切接触的其他家庭成员是儿童感染的重要传染源,故已感染Hp的父母或其他家庭成员同步接受Hp根治治疗,对提高患儿Hp根除率与预防再感染有重要意义.
展开▼
