急性脑梗死患者血清胶质纤维酸性蛋白和S100-β蛋白水平变化

摘要

Objective To explore the role of serum glial fibrillary acidic protein and S100-β protein, the relations of infarct volume and scores of neurologic impairment of patients with acute cerebral infarction. Methods We serially (on 3rd ,7th , and 14th day) measured the serum levels of GFAP and S100-β protein by enzyme linked immunosorbent assay (ELISA). We also analyzed the relations of infarct volume with scores of neurologic impairment. Results Expressions of GFAP were significantly increased (on 3rd, 7th, and 14th day) in trerapy group compared with that of control group. Highest expression of GFAP occurred on 7th day, and they remained significantly elevated on 14th day after pathogenesy. Highest expression of S100-β protein occurred on 3rd day, and they were normal on 7th day and 14th day after pathogenesy. Expression of GFAP and expression of S100-β protein were all correlated with infarct volume and scores of neurologic impairment. Conclusion GFAP and S100-β protein may play an important role in the pathophysiology of pristine pathogenesy, physiology and repair process. Serum levels of GFAP and S100-β protein can provide the basis for diagnosis and treatment of ACI.%目的 探讨胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)和S100-β蛋白在急性脑梗死(acute cerebral infarction,ACI)发病中的作用及其与脑梗死面积、神经功能缺损评分的关系.方法 应用双抗体夹心酶联免疫吸附法( ELISA)连续测定ACI患者发病后第3、7、14天时GFAP和S100-β蛋白血清浓度,并分析其与脑梗死面积、神经功能缺损评分的关系.结果 GFAP血清水平在ACI发病第3、7、14天均高于对照组,并且GFAP高峰时间在发病第7天,并持续增高到发病后第14天；S100-β蛋白高峰时间在发病后第3天,并在发病后第7、14天恢复正常.GFAP、S100-β蛋白的血清浓度与脑梗死的面积、神经功能缺损程度均相关.结论 GFAP和S100-β蛋白可参与ACI发病早期的病理、生理及修复过程,故检测两者的血清浓度对于及早诊治本病有重要意义.