阿司匹林与氯吡格雷双重抗血小板治疗急性脑梗死的效果观察

摘要

Objective To observe the effect of dual antiplatelet therapy with aspirin and clopidogrel for the treatment of acute cerebral infarction. Methods 82 patients with acute cerebral infarction were randomly divided into two groups, with 41 cases in each group. The control group was treated with aspirin, while the observation group was treated with aspirin and clopidogrel. The clinical effects of two groups were compared. Results After therapy, the serum CRP level, serum fibrinogen level, Berghel score and NIHSS score of observation group were significantly lower than those of control group (P<0.05). The total effective rate of observation group was 95.1%, significantly higher than 75.6% of control group (P<0.05). Conclusions Dual antiplatelet therapy with aspirin and clopidogrel for the treatment of acute cerebral infarction can effectively reduce the levels of serum CRP and fibrinogen. It is effective and safe, and worthy of clinical application.%目的 观察阿司匹林与氯吡格雷双重抗血小板治疗急性脑梗死的临床效果. 方法 82例急性脑梗死患者随机分为两组各41例, 对照组单纯使用阿司匹林进行治疗, 观察组在此基础上联合氯吡格雷进行治疗, 比较两组的临床效果. 结果 治疗后观察组血清CRP水平及纤维蛋白原均显著低于对照组 (P <0.05). 观察组总有效率为95.1%, 显著高于对照组的75.6% (P <0.05). 治疗后观察组Berghel评分及NIHSS指数评分均显著低于对照组 (P<0.05). 结论 联合氯吡格雷与阿司匹林双重抗血小板治疗急性脑梗死, 可降低血清CRP水平及纤维蛋白原, 其疗效安全可靠, 值得临床应用及推广.