高通量血液透析在肺心病心力衰竭中的应用研究

摘要

Objective To explore the application value of high flux hemodialysis in pulmonary heart disease complicating heart failure. Methods 60 patients with pulmonary heart disease complicating heart failure treated in our hospital from July 2014 to August 2015 were randomly divided into two groups, with 30 cases in each group. The control group was given conventional treatment, the observation group was given high-flux hemodialysis treatment on this basis. The clinical effect, changes of blood gas analysis (ABG) indices and renal function indices of the two groups were compared. Results After treatment, the total effective rate of the observation group was 96.67%, higher than 70.00%of the control group (P<0.01);after treatment, the ABG indices (including PaO2, PaCO2, SaO2) of the two groups were improved, and the improvement degree of the observation group was better than that of the control group (P <0.01); the renal function indicators (BUN, Scr,β2-MG) and MMS level of the observation group were improved, and better than those of the control group (P<0.01). Conclusions Routine treatment combined with high-flux hemodialysis has significant effect in treatment of pulmonary heart disease complicating heart failure, and can effectively improve the patients' ABG indices, which has high safety and deserves promotion in clinic.%目的：探讨高通量血液透析在肺心病心力衰竭中的应用价值。方法收集我院2014年7月至2015年8月收治的60例肺心病心力衰竭患者，随机分为两组各30例。对照组给予常规治疗，观察组在此基础上联合高通量血液透析治疗。比较两组的临床疗效、血气分析及肾功能指标等变化情况。结果治疗后观察组总有效率为96.67%，明显高于对照组的70.00%，差异有统计学意义(P＜0.01)；治疗后两组患者血气分析指标(PaO2、 PaCO2、 SaO2)均较治疗前明显改善，且观察组改善程度优于对照组(P＜0.01)；治疗后观察组肾功能指标(BUN、 Scr、β2-MG)及MMS均显著改善，明显优于对照组(P＜0.01)。结论在常规治疗基础上联合高通量血液透析治疗肺心病心力衰竭疗效显著，可有效改善患者的血气分析指标，安全性高，值得临床推广应用。