Objective To study the effect of nasal intermittent positive pressure ventilation (NIPPV) in the treatment of neonatal severe hypercapnia. Methods 168 cases of children with severe hypercapnia were randomly divided into intermittent group and mechanical group, with 84 cases in each group. The intermittent group was given NIPPV on the basis of foundation treatment, the mechanical group was given mechanical ventilation, all patients received comprehensive nursing. The arterial blood gas indexes (including pH, PaCO2, PaO2) before treatment, after 2 h and 12 h of treatment between two groups were observed, the cerebral hemodynamic indexes (including Vs, Vd, S/D, RI, PI) were analyzed. Results The duration of ventilation, arterial blood gas indexes before and after treatment, cerebral hemodynamic indexes between two groups had no statistical difference (P>0.05), but the arterial blood gas indexes after 2 h and 12 h of treatment in two groups were significantly improved (P<0.05). The complications rate of intermittent group was 1.19%, lower than 8.33%of mechanical group, with statistical difference (P <0.05). Conclusions NIPPV has significant effect in the treatment of neonatal severe hypercapnia with less complications, which has high clinical value.%目的：探讨经鼻间歇正压通气(晕陨PP灾)治疗新生儿严重高碳酸血症的疗效。方法将我院168例新生儿严重高碳酸血症患者随机分成间歇组和机械组各84例，间歇组在基础处理的基础上采用晕陨PP灾治疗，机械组采用机械通气治疗，两组均给予全面护理。观察两组患儿治疗前，治疗后2澡及12澡的动脉血气指标(责匀、P葬悦韵2、P葬韵2)，并分析两组患儿的脑血流指标(灾泽、灾凿、杂/阅、砸陨、P陨)的情况。结果两组的通气时间、治疗前后的动脉血气指标、脑血流指标相比差异均无统计学意义(P>0.05)，但两组治疗后2澡及12澡的动脉血气指标均明显改善(P<0.05)。间歇组的并发症发生率为1.19豫，显著低于机械组的8.33豫，差异有统计学意义(P<0.05)。结论晕陨PP灾治疗新生儿严重高碳酸血症疗效显著，并发症少，具有较高的临床价值。
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