Objective To investigate the level of serum vaspin in the maintenance hemodialysis patients and the relationship between vaspin level and insulin resistance.Methods 48 patients with end-stage renal disease (including 18 cases of diabetes and 30 cases of non-diabetes mellitus) were involved in this study,and 30 cases of normal healthy volunteers served as the control group.Serum vaspin was detected in three groups together with the following aspects; triglycerides, total cholesterol, high density lipoprotein-chdesterol, low-density lipoprotein-chdesterol, total protein, albumin,serum insulin, and fasting blood glucose(FBG),isulin sensitivity index, insulin resistance index, waist-to-hip ratio(WHR) and body mass index(BMI) were calculated and analyzed.Results ①The level of serum vaspin in maintenance hemodialysis patients was lower than that of normal group,(0.91±0.36)μg/L vs (1.15±0.31) μg/L( P 0.05).Conclusion Glucose,lipid metabolism disorders and insulin resistance exist in maintenance hemodialysis patients.The lower level of serum vaspin is correlated with renal function,but it is not correlated with insulin resistance index.%目的 探讨维持性血液透析患者血清vaspin的水平及其与胰岛素抵抗的关系.方法 选取我院透析中心终末期肾病维持性血液透析患者48例,测定血脂、尿素氮(BUN)、肌酐(Cr)、尿酸(UA)等指标,并抽血测定血清vaspin、血清胰岛素(FIns)、血糖(FBG),计算胰岛素敏感指数(ISI),胰岛素抵抗指数(HOMA-IR)及腰臀比(WHR)、体质量指数(BMI),根据是否有糖尿病分为糖尿病组18例和非糖尿病组30例,同时选取30例健康体检者作为对照组,并对相关数据进行统计分析.结果 ①维持性血液透析患者血清vaspin水平较正常对照组降低,(0.91±0.36)μg/L vs (1.15±0.31) μg/L(P＜0.01).②糖尿病组和非糖尿病组两组患者的血清vaspin水平差异无统计学意义,(0.87±0.38) μg/L vs (0.97±0.34) μg/L(P＞0.05).③相关分析显示:vaspin除与BUN、Cr、UA、WHR相关外,尚与性别有关(r=-0.294、-0.284、一0.278、-0.375、0.244,P＜0.05),其中,女性vaspin水平高于男性(1.11±0.38) μg/L vs (0.93±0.33) μg/L(P＜0.05).vaspin与HOMA-IR、FIns、FBG、年龄、BMI则没有相关性(r=-0.098,-0.146,0.049,-0.095、-0.182,P＞0.05).结论 在维持性血液透析中存在有糖脂代谢紊乱和胰岛素抵抗,血清vaspin水平下降,与肾功能相关,但与胰岛素抵抗不相关.
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