Objective To analyze the incidence and clinical feature of urothelial carcinoma in renal allograft recipients for the diagnosis and treatment. Methods A retrospective analysis was performed on 1 042 renal allografts who had taken immunosuppression for at least over six months between Jan. 2006 and Jul. 2011 in the First Centre Hospital of Tianjin. Results Twevle cases(1.2%) of uroepithelial carcinoma were found in 1 042 cases of renal transplantation, of which 9 cases(75. 0% ) were diagnosed on account of hematuria,3 cases (25. 0% ) were diagnosed by health examination. Surgery was performed on all the patients. The treatment included surgical treatment and chemical therapy. Conclusion Malignancies in urinary tract after renal transplantation should get more attention from clinicians. Early diagnosis is very important. The treatment includes the decrease of immunosuppressive agents and the complete removal of the tumor lesion.%目的 探讨总结肾移植术后受者并发自体尿路上皮肿瘤的发生率、临床特征、诊治体会及原因分析.方法 回顾性分析了我院2006年1月至2011年7月1 042例肾移植术后接受至少6个月的免疫抑制治疗受者的病历资料.结果 在1 042例肾移植受者中,发生尿路上皮肿瘤者为12例,发生率为1.2％,全部病历资料完整,其中9例(75.0％)因血尿就诊,3例(25.0％)因查体发现,包括1例自感尿频,1例因腰病就医而诊断.所有患者均经手术治疗.生存良好9例,死亡3例.结论 对肾移植后并发尿路上皮肿瘤的患者要高度重视,对血尿症状要高度警惕,重视术后检查,密切随访,早期诊断,积极行根治性手术治疗,减少免疫抑制剂的用量.
展开▼
