搅拌釜内液-液混合溶析沉淀法制备纳米姜黄素颗粒

摘要

The preparation of Curcumin nanoparticles was realized in a small stirred tank by the anti-solvent precipitation process. The influences of such factors as tank size, stirring style, initial concentration and rotation speed on nanoparticle preparation were investigated. Meanwhile, planar laser induced fluorescence (PLIF) technique was used to quantitatively measure the liquid-liquid mixing performance in the tank, and the mixing environment was found to be important for the preparation of nanoparticles. A low stirring speed in a small stirred tank with a turbine impeller could not achieve the desired mixing efficiency because of agglomeration of nanoparticles. An overly high stirring speed brought in strong shearing interaction between particles and fluid so that many particles were broken up. Overly high over-saturation in local areas would cause growth and agglomeration of particles. The optimal mixing environment with moderate process intensification was crucial to successfully prepare high quality Curcumin nanoparticles with spherical shape and narrow size distribution.%研究了在搅拌釜内利用溶析沉淀法制备姜黄素纳米颗粒的过程,分别探讨了搅拌釜尺寸、搅拌形式、初始浓度以及搅拌转速对制备结果的影响.通过平面激光诱导荧光技术定量测量釜内液液混合行为,揭示了流体混合环境的控制是决定溶析沉淀产品过程的关键因素.实验表明,搅拌速度过低无法保证流体混合效率,将导致颗粒黏结;搅拌速度过高带来颗粒与流场的强剪切作用,引起颗粒破碎;局部过饱和度过大,引起颗粒的生长和聚团.搅拌釜内纳米颗粒制备需提供适度强化的流体混合环境.