腹腔热灌注联合全身化疗治疗恶性腹腔积液的疗效观察

摘要

Objective To observe the curative effect of intraperitoneal chemohyperthermia (IPCH) combined with systemic chemotherapy on malignant ascites and discuss the complementary treatment of malignant cancer. Methods 102 cases of advanced cancer with medium or large amount of malignant ascites were chosen and divided randomly into treatment group(using IPCH combined with systemic chemotherapy,n = 52) and control group (using systemic chemotherapy,n = 50). Short-term effect and adverse reaction of patients in the two groups were observed. Results The rates of complete remission,partial remission and clinical benefit of patients in treatment group (38. 5% ,42. 3% and 90. 3% respectively) were higher than those in control group(14. 0% , 16. 0% and 66. 0%, respectively) (P<0. 05). Comparison of adverse reaction between two groups revealed no statistically significant difference (P>0. 05). Conclusion IPCH combined with systemic chemotherapy can effectively control malignant ascites.%目的 观察腹腔热灌注(IPCH)联合全身化疗对恶性腹腔积液的治疗效果,探讨恶性肿瘤的辅助治疗措施.方法 选择具有中至大量恶性腹腔积液的晚期肿瘤患者102例,随机分为治疗组(腹腔热灌注联合全身化疗,n=52)和对照组(全身化疗,n=50),观察两组的近期疗效及不良反应.结果 治疗组患者的完全缓解率、部分缓解率及临床受益率(分别为38.5%、42.3%及90.3%)均高于对照组(分别为14.0%、16.0%及66.0%)(P＜0.05),两组不良反应比较,差异无统计学意义(P＞0.05).结论 IPCH联合全身化疗能有效地控制恶性腹腔积液.