舒芬太尼预防雷米芬太尼麻醉后早期疼痛的临床疗效

摘要

Objective To investigate the clinical efficacy of sufentanil prevention for early pain after anesthesia by remifentanil. Methods 122 cases were selected and divided into two groups , fentanyl group(n= 61) , sufentanil group(n=61). After the treatment we compared the clinical data of the three groups. Results There was significant different in the VAS scores after operation 1 h,2 h,4 h,6 h and rates of additional anesthetic drugs does between two groups(P<0. 05). However,there were no difference in recovery time of consciousness,spontaneous breathing recovery time,extubation time,postoperative HR,MAP and SpO2 and the incidence of adverse reactions between two groups(P>0. 05). Conclusion This study indicates that sufentanil has better clinical efficacy of prevention for early pain after anesthesia by remifentanil than that of fentanyl.%目的 研究舒芬太尼预防雷米芬太尼麻醉后早期疼痛的临床疗效.方法 入选2008年2月至2011年8月期间在该院予以雷米芬太尼麻醉行胸部手术患者122例,按照入院先后顺序编号,根据随机数字方法分成芬太尼组和舒芬太尼组各61例.比较术后两组患者的疼痛治疗效果.结果 舒芬太尼组患者术后1、2、4及6 h的疼痛情况视觉模拟评分(VAS)均较芬太尼术后对应时间的VAS显著降低(P<0.05),芬太尼组与舒芬太尼组需要追加芬太尼剂量的发生率分别为50.82%和4.92%,两组比较差异有统计学意义(P<0.05).而两组患者的意识恢复时间、自主呼吸恢复时间、拔管时间、术后心率(HR)、平均动脉压(MAP)和脉搏氧饱和度(SpO2)以及不良反应发生率方面比较差异均无统计学意义(P>0.05).结论 舒芬太尼对雷米芬太尼麻醉后早期疼痛具有较好的临床效果,显著优于芬太尼.