重庆地区妇女人乳头瘤病毒感染的调查分析

摘要

Objective To analyze the infection rate and type distribution of human papilloma virus (HPV) of women in Chongqing region and their correlation with cervical diseases. Methods Fast nucleic acid hybridization microchip was employed to detect the HPV in cervical cells. The HPV infection rate, type distribution and their correlation with cervical diseases were analyzed. Results A total of 7016 samples were detected. HPV positive rate was 33. 6%. 1558 patients (66. 1%) showed positive HPV with high-risk type and mainly in subtypes 16,58,52,33,18,31,68 of HPV. 447 patients (19. 0%) showed positive HPV with high-risk type combined with the other type and mainly in subtypes 16,52,58 of HPV. 23 patients (1. 0%) were found positive HPV with low-risk type combined with the other type and mainly in subtypes 6,52 of HPV. 159 patients (6. 7%) demonstrated positive HPV with low-risk type and mainly in subtypes 11,6 of HPV,and 170 patients (7. 2%) with the other type and mainly in subtypes CP8304 ,53 of HPV. The cervical lesion degree showed positive correlation with HPV infection. Conclusion HPV infection rate of women in Chongqing region is relatively high, and HPV-DNA detection has important value in early diagnosis and prevention of cervical malignant lesions.%目的 分析重庆地区妇女人乳头瘤病毒(HPV)的感染率、型别分布及其与宫颈疾病的相关性.方法 用核酸分子芯片快速杂交法检测宫颈细胞HPV,并对HPV感染率、型别分布及其与宫颈疾病的相关性进行分析.结果 共检测7 016例标本,HPV阳性率为33.6%,高危型阳性1 558例(66.1%),型别以HPV 16、58、52、33、18、31、68亚型为主;高危型合并其他型阳性447例(19.0%),型别以HPV 16、52、58亚型为主;低危型合并其他型阳性23例(1.0%),以HPV 6、52亚型为主;低危型159例(6.7%),以HPV 11、6亚型为主;其他型170例(7.2%),以HPV CP8304和53亚型为主.宫颈病变程度与HPV感染呈正相关.结论 重庆地区妇女HPV感染率相对较高,HPV-DNA检测对宫颈恶性病变的早期诊断和预防有重要价值.