联合检测血清胱抑素C和同型半胱氨酸在2型糖尿病肾病早期诊断中的意义

摘要

Objective To explore the significance of combined detection of serum cystatin C(Cys C) and homocysteine(Hcy) in early diagnosis of type 2 diabetic nephropathy. Methods 70 patients with type 2 diabetes mellitus divided into diabetic nephropathy group(n=50) and diabetes without kidney injury group(n -20) according to the diagnostic criteria for diabetic nephropathy, and 50 healthy people served as normal control group. Serum reatinine,blood urea nitrogen,glycated hemoglobin (GHbAlc) , urinary albumin excretion rate (UAKR) ,Cys C and Hcy of patients in the three groups were detected simultaneously. Results Levels of serum creatinine,bloos urea nitrogen,UAER and Cys C of patients in diabetic nephropathy group were significantly higher than those in diabetes without kidney injury group and normal control group(P<0. 05). Compared levels of GHbAlc of patients in diabetic nephropathy group and diabetes without kidney injury group with those in normal control group,respectively,differences showed statistically significance(P<0. 05). Conclusion Combined detection of Cys C and Hcy can serve as an important indicator for early diagnosis of kidney injury in patients with type 2 diabetic nephropathy.%目的 探讨联合检测血清胱抑素C(Cys C)和同型半胱氨酸(Hcy)在2型糖尿病肾病早期诊断中的意义.方法 将70例2型糖尿病患者按糖尿病肾病诊断标准分为糖尿病肾病组(n=50)与糖尿病无肾损伤组(n=20),选择50例健康人作为正常对照组.同时检测3组患者的肌酐、尿素氮、糖化血红蛋白(GHbA1c)、尿微量清蛋白排泄率(UAER)、Cys C和Hcy.结果 糖尿病肾病组患者肌酐、尿素氮、UAER及Cys C水平高于糖尿病无肾损伤组和正常对照组(P＜0.05);糖尿病肾病和糖尿病无肾损伤组分别与正常对照组的GHbA1c水平比较,差异有统计学意义(P＜0.05).结论 联合检测Cys C和Hcy可作为2型糖尿病肾病患者肾损害早期诊断的重要指标.