Objective To observe the dynamic change of brain natriuretic peptide (BNP) in plasma of elderly patients with hy-pertensive intracerebral hemorrhage ,and to explore the relationship between BNP levels and cerebral edema .Methods 56 elderly patients with hypertensive intracerebral hemorrhage were recruited and divided into the operation group (n=26) and the non-opera-tion group(n=30) ,25 hypertensive patients were collected as the control group .ELISA was applied to detect the levels of plasma BNP at 6 ,24 ,72 ,168 h after the onset of hypertensive intracerebral hemorrhage .The non-invasion brain edema monitor was utilized to dynamically monitor the cerebral edema degrees .Results The plasma BNP levels in the operation group and the non-operation group at 6 ,24 ,72 ,168 h were higher than those in the control group ,the differences showed statistical difference (P<0 .05) ,but which at 168 h in the operation group was lower than that in the non-operation group ,cerebral edema appeared at 24 h in the two groups ,and reached the peak value at 72 h in the operation group and at68 h in the non-operation group;the changes of plasma BNP levels had positive correlation with cerebral edema degree (r=0 .685 ,P<0 .05) .Conclusion Dynamic monitoring of plasma BNP levels is an effective indicator for early diagnosis and monitoring of acute brain edema in elderly patients with hypertensive in-tracerebral hemorrhage .%目的：观察高血压性脑出血老年患者血浆脑钠肽（BNP）的动态变化，探讨血浆BNP水平与脑水肿的关系。方法：将56例高血压脑出血老年患者分为手术组（26例）和非手术组（30例），25例老年高血压患者为对照组。在发病后6、24、72、168 h采用酶联免疫吸附试验法定量检测BNP血浆浓度，用无创脑水肿动态监护仪测定脑水肿程度。结果手术组和非手术组血浆BNP含量在6、24、72、168 h高于对照组，差异有统计学意义（P＜0．05），而手术组BNP含量在168 h低于于非手术组；两组患者在24 h开始发生脑水肿，手术组72 h达高峰，非手术组168 h达高峰；血浆BNP水平变化与脑水肿程度呈正相关（r＝0．685，P＜0．05）。结论：动态观察血浆BNP含量是早期诊断和监测高血压性脑出血老年患者急性期脑水肿的有效指标。
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