Objective To study the influence of transvaginal hysterectomy on the human immune function. Methods 94 patients with benign uterine diseases scheduled for hysterectomy from October 2009 to May 2011 were chosen and divided into the transvag inal group(VH,31 cases) ,the laparoscopic group(LH,33 cases) and the open surgery group(AH,30 cases). The levels of CD30, CD69,interleckin 6(IL 6) ,interleckin 8(IL 8) and C reactive protein(CRP) before operation and at postoperative 24,72 h were measured and compared among 3 groups. Results The CD30 and CD69 levels at postoperative 24 in the AH group were increased more significantly(P<0. 05) ,while the difference between the VH group and LH group had no statistical significance(P>0. 05). The IL 6 and CRP levels at postoperative 24,72 h in 3 groups were significantly increased than before operation with statistical difference(P-<0. 05). The IL 6 and CRP levels at postoperative 24 ,72 h in AH group were higher than those in the VH group and the LH group statistical difference(P<0. 05). Conclusion Transvaginal hysterectomy and laparoscopic hysterectomy have the sirn ilar depressive degrees on the immune function.%目的 探讨经阴道子宫切除术对机体免疫功能的影响.方法 选择2009年10月至2011年5月该院因子宫良性疾病需行子宫全切术患者94例,按病情及患者的意愿分为经阴道组31例,腹腔镜组33例,开腹组30例,比较3组患者术前及术后24、72 h的CD30、CD69、IL-6、IL-8以及CRP水平.结果术后24 h CD30、CD69水平开腹组升高更明显,差异有统计学意义(P<0.05),而经阴道组与腹腔镜组比较差异无统计学意义(P>0.05).3组患者术后24、72 h IL-6、CRP水平较术前显著升高,差异有统计学意义(P<0.05),术后24、72 h IL-6、CRP水平开腹组高于经阴道组和腹腔镜组,差异有统计学意义(P<0.05).结论经阴道与腹腔镜子宫切除术对机体免疫抑制程度相似.
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