胆结石患者血清CA19-9、CEA表达与胆管炎症的关系

摘要

Objective To investigate the clinical significance of serum CA19 9 and CEA level in patients with cholelithiasis.rnMethods The clinical data of 106 patients with cholelithiasis and 48 patients with inguinal hernia from Mar. 2008 to Dec. 2011 werernanalyzed. The serum level of CA19 9 and CEA were measured pre operation and after operation. The relation between clinical datarnand cholelithiasis was analyzed. Results The serum level of CA19 9 and CEA were normal in 56 patients (52. 8%) and no signifirncant difference was observed comparing with inguinal hernia group (P>0. 05). 48 cases of them (85. 7%) were with cholecystolithrniasis,and 8 cased of them (14. 3%) were with common bile duct calculi. The serum level of CA19 9 and CEA were increased in 50rnpatients (47. 2%) and were significant higher than that of inguinal hernia group (P<0. 01). 7 cases of them (14%) were with sernvere cholecystitis,and 43 cases of them (86%) were with common bile duct calculi. The level of CA19 9 and CEA were significantlyrnincreased in patients with severe suppurative obstructive cholangitis or severe pancreatitis,and decreased after operation. ConclusionrnThe serum level of CA19 9 and CEA are increased in patients with cholelithiasis, and may be a reference marker for cholelithiasis.%目的 探讨血清糖类抗原19-9(CA19-9)、癌胚抗原(CEA)表达水平在胆结石患者中的临床意义.方法 回顾分析2009年3月至2011 年12月106例胆结石患者和48例腹股沟疝患者的临床资料,所有患者手术前后检测血清CA19-9、CEA表达水平,分析二者表达水平在胆结石疾病中的临床意义.结果 56例(52.8%)胆结石患者血清CA19-9、CEA表达水平正常,与腹股沟疝患者比较差异无统计学意义(P>0.05),其中胆囊结石48例(85.7%),胆总管结石8例(14.3%);50例(47.2%)胆结石患者血清CA19-9、CEA表达水平增高,并显著高于腹股沟疝患者(P<0.01),其中严重胆囊炎7例(14%),胆总管结石43例(86%),且显著增高患者合并有化脓性梗阻性胆管炎或胰腺炎.血清CA19-9、CEA增高患者经手术治疗后表达水平下降.结论 血清CA19-9和CEA在胆结石患者中可表达增高,可作为判断胆道炎症的参考指标.