Objective To understand syphilis infection status of pregnant and puerperal women in Wuhan and provide basis to prevent fetus or newborns from congenital syphilis infection .Methods 41 ,709 pregnant women receiving prenatal medical examination and puerperal women receiving hospital delivery in Wuhan were served as respondents .1 mL of serum of each respondent was collected ,and enzyme-linked immunosorbent assay (ELISA) was employed to detect syphilis antibody in serum .Positive sera which was screened out were subjected to further treponema pallidum particle assay (TPPA) and toluidine red untreated serum test(TRUST).Diagnosis of syphilis infection was made by combining with clinical and epidemiological data .Results Current morbidity of syphilis of pregnant and puerperal women was 2.73‰,their rate of previous syphilis infection was 5 .87‰ .The current morbidities and previous infection rates of syphilis showed obvious rising tendency with increasing age of pregnant and puerperal women , and they did not present significant difference in different pregnant stages .Conclusion Pregnant and puerperal women in Wuhan possess a lower current morbidity and higher previous infection rate of syphilis .Prevention of syphilis infection among preconception childbearing-aged women should be strengthened .%目的 了解武汉市孕产妇梅毒感染状况,为预防胎儿或新生儿先天性梅毒感染提供依据.方法 以武汉市接受产前医学检查的孕妇及住院分娩产妇(共计41 709例)为调查对象.采集孕产妇血清1 mL,用酶联免疫吸附测定(ELISA)法筛查血清梅毒抗体,对筛出的阳性血清,再用梅毒螺旋体明胶凝集试验(TPPA)和甲苯胺红不加热血清试验(TRUST)方法进行检测,结合临床资料和流行病学综合判断梅毒感染.结果 孕产妇的梅毒现患率为2.73‰,孕产妇既往梅毒感染率为5.87‰;孕产妇的梅毒现患率和既往梅毒感染率随年龄增长有显著上升趋势;各孕期孕妇的梅毒现患率和既往梅毒感染率的差异无统计学意义.结论 武汉市孕产妇梅毒现患率较低,但既往梅毒感染率较高,孕前育龄妇女梅毒感染的防治应加强.
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