Objective To observe the effects of Uremic Clearance Granule combined with angiotensin receptor blockers (ARB) or angiotensin converting enzyme inhibitors (ACEI) in treating different period of diabetic nephropathy (DN ) .Methods 46 patients with DN were divided into the control group and the treatment group ,23 cases in each group .The two groups were given the rou-tine hypoglycemic therapy .The control group was treated with ACEI or ARB ,while the treatment group was given Uremic Clear-ance Granule 5 g each time ,four times daily for successive 4 weeks .Then the indexes of serum creatinine ,blood urea nitrogen ,cysta-tin-C ,microalbumin and 24 h urine total protein at 24 h before and after treatment were observed .Results The microalbumin and 24 h urine total protein after treatment in the two groups were reduced compared with before treatment (P<0 .01) .In the patients with the stage Ⅲ of DN ,the urine protein decrease after treatment had no statistical difference between the two groups (P>0 .05) . In the patients with the stage Ⅳ of DN ,on the basis of ACEI or ARB adding Uremic Clearance Granule could significantly decrease the urine protein(P<0 .05) .Conclusion ACEI or ARB combined with Uremic Clearance Granule has definite effect for treating massive proteinuria of DN .%目的:观察尿毒清颗粒联合血管紧张素转换酶抑制剂(ACEI)或血管紧张素受体拮抗剂(ARB)类药物对糖尿病肾病不同分期的疗效。方法将46例糖尿病肾病患者分为对照组和治疗组,每组各23例。两组患者均常规降糖治疗,对照组给予ACEI或ARB类药物;治疗组在对照组治疗的基础上联用尿毒清颗粒每日4次,每次5 g ,连续服药4周,观察治疗前后24 h尿微量蛋白、24 h尿蛋白定量、血肌酐、尿素氮、胱抑素的变化。结果两组治疗后24 h尿微量蛋白、24 h蛋白定量均较治疗前减少(P<0.01)。对于糖尿病肾病Ⅲ期患者,治疗组和对照组在减少尿蛋白的治疗上差异无统计学意义(P>0.05),对于糖尿病肾病Ⅳ期患者,治疗组较对照组尿蛋白明显减少(P<0.05)。结论 ACEI或ARB类药物联合尿毒清颗粒治疗糖尿病肾病大量蛋白尿患者疗效确切。
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