B cl-6共抑制因子样蛋白及E钙黏蛋白在胃癌中的表达及相关性分析

摘要

Objective To investigate the expression of BCORL1 and E-cadherin and their correlation analysis in gastric carcino-ma .Methods We freshly collected 58 samples of surgically resected paired gastric carcinoma and normal tumor-adjacent tissues and detected BCORL1 and E-cadherin expression in the samples using immunohistochemical staining .The correlation between BCORL1 and E-cadherin protein expression was analysed .Results The protein expression of BCORL1 in gastric carcinoma tissues was sig-nificantly upregulated compared to those of the normal tumor-adjacent tissues(60 .3% vs .17 .2% ,P=0 .000) ,but expression of E-cadherin in gastric carcinoma tissues was significantly lower than those in the normal tumor-adjacent tissues (27 .6% vs .63 .8% , P=0 .000) .Clinicopathological analysis suggested that EphA2 and E-cadherin protein expression were associated with histopatho-logical differentiation ,depth of invasion ,lymph node metastasis and TNM stage(P<0 .05) .BCORL1 was significantly negative cor-related with E-cadherin protein in gastric carcinoma(r= -0 .571 ,P=0 .002) .Conclusion The high-expression of BCORL1 is cor-related with malignant clinicopathological characteristics ,and BCORL1 is negative associated with E-cadherin ,suggesting that BCORL1 promotes tumor progression and metastasis through transcriptional regulating E-cadherin in gastric carcinoma .%目的：检测Bcl-6共抑制因子样蛋白1（BCORL1）及E钙黏蛋白（E-cadherin）在胃癌及对应的癌旁组织中的表达情况，分析二者表达的相关性。方法收集58例胃癌及对应癌旁组织，运用免疫组织化学技术检测BCORL1及E-cadherin的表达情况，分析二者表达的相关性。结果 BCORL1在胃癌组织中的表达显著高于对应的癌旁组织（60．3％ vs ．17．2％，P＝0．000），而E-cadherin在胃癌组织中的表达显著低于对应的癌旁组织（27．6％ vs ．63．8％，P＝0．000）；BCORL1及E-cadherin表达与肿瘤组织病理分化、浸润深度、淋巴结转移和 TNM 分期相关（P＜0．05）；胃癌组织中 BCORL1与 E-cadherin 表达呈负相关（r＝-0．571，P＝0．002）。结论胃癌组织中BCORL1高表达与恶性临床病理参数相关，并与 E-cadherin表达呈负相关，提示BCORL1可能通过转录抑制E-cadherin ，促进胃癌进展和转移。