布拉酵母菌与双歧杆菌四联活菌治疗小儿轮状病毒性胃肠炎疗效比较

摘要

目的：比较布拉酵母菌散与双歧杆菌四联活菌片在治疗小儿轮状病毒性胃肠炎的临床疗效。方法选择2012年1月至2014年5月在第三军医大学西南医院儿科门诊及住院部就诊患儿，年龄在2个月至8岁的轮状病毒性胃肠炎患儿191例，按随机数字表法分为对照组（蒙脱石散及常规对症治疗，n＝62）、双歧杆菌四联活菌片组（常规治疗＋双歧杆菌四联活菌片，n＝64）、布拉酵母菌散组（常规治疗＋布拉酵母菌散，n＝65），治疗第3天及第5天后比较各组的治疗效果。结果双歧杆菌四联活菌片组、布拉酵母菌散组的显效、有效和总有效率均明显高于对照组，差异有统计学意义（P＜0．05）。而布拉酵母菌散组的显效和总有效率指标稍高于双歧杆菌四联活菌片组，但差异无统计学意义（P＞0．05）。双歧杆菌四联活菌片组、布拉酵母菌组在治疗第3天、第5天大便次数及腹泻持续时间均明显低于对照组，差异有统计学意义（P＜0．05）。布拉酵母菌散组腹泻持续时间较双歧杆菌四联活菌片组明显缩短，差异有统计学意义（P＜0．05）。结论布拉酵母菌散与双歧杆菌四联活菌片两种益生菌治疗儿童轮状病毒性胃肠炎的疗效相似，布拉酵母菌散较双歧杆菌四联活菌片可以缩短腹泻持续时间。%Objective To compare the effect between Saccharomyces boulardii sachets and tetragenous viable bifidobacterium tablets in the treatment of rotaviral gastroenteritis of children .Methods A total of 191 patients (below 2 months to 8 years old) with rotaviral gastroenteritis admitted to this hospital from January 2012 to May 2014 were divided randomly into control groups (smectite ,conventional treatment ,number=62) ,tetragenous viable bifidobacterium tablets group (conventional treatment combined with tetragenous viable bifidobacterium tablets ,number= 64) ,saccharomyces boulardii group (conventional treatment combined with saccharomyces boulardii ,number=65) .Therapeutic effects were compared between 3 groups after 3 days and 5 days of treat‐ment .Results The obvious curative rate ,effective ratio and total rate in the groups of saccharomyces boulardii and tetragenous via‐ble bifidobacterium tablets were higher than those in the control group(P<0 .05) .However ,no significant difference was found in the two cases among the groups (P>0 .05) .There was significant difference in 3 days and 5 days therapeutic effect among 3 groups (P<0 .05) .The duration of diarrhea in the group of Saccharomyces boulardii was lower than this in the group of tetragenous viable bifidobacterium tablets (P<0 .05) .Conclusion The therapeutic effect of Saccharomyces boulardii is similar to that of tetragenous viable bifidobacterium tablets in treatment of children with Rotaviral gastroenteritis .The duration of diarrhea in the group of Sac‐charomyces boulardii was lower than that of the group of tetragenous viable bifidobacterium tablets .