吲哚菁绿荧光血管造影在颅内动脉瘤夹闭术中的应用

摘要

Objective To improve the safety of surgery,the application of indocyanine green fluorescein(ICG)angiography in intracranial aneurysm surgery was investigated.Methods Fifty cases of intracranial aneurysms were retrospectively analyzed.All the patients were received ICG angiography before and after intracranial aneurysm clipping.The efficiency of the surgery was evalu-ated with CT angiography(CTA)and(or)digital subtraction angiography(DSA).The postoperative follow-up was conducted using Glasow outcomes score(GOS).Results Of the 50 patients,3 cases of aneurysmal neck remnant,one case of parent arteries steno-sis,one case of nearby branch stenosis and two cases of “false-negative”were observed after ICG angiography.The clips were adjus-ted until the satisfactory blood flew was restored.Postoperative CTA and(or)DSA confirmed the results of intraoperative ICG an-giography.Of the 40 patients underwent follow-up,GOS score was 5 in 30 cases,4 in 7 case,3 in 2 case and 2 in 1 case.Conclusion ICG angiography is a useful way to assess the clipping of aneurysms,blood flew of parent arteries and nearby branches during the aneurysm surgery.It could raise the safety of surgery and further improve the clinical outcomes of intracranial aneurysms.%目的：探讨吲哚菁绿荧光血管造影在颅内动脉瘤夹闭术中的应用,提高手术安全性。方法回顾性分析该科室50例术中应用荧光血管造影的颅内动脉瘤患者资料。术中动脉瘤夹闭前后均行吲哚菁绿荧光血管造影,术后行头颅 CT 血管造影(CTA)和(或)数字减影血管造影(DSA)随访检查,观察治疗效果并采用格拉斯哥(GOS)评分进行术后随访。结果术中吲哚菁绿荧光血管造影发现动脉瘤颈残留3例,载瘤动脉及动脉瘤临近分支血管狭窄各1例,吲哚菁绿荧光造影“假阴性”2例,均根据情况调整动脉瘤夹,再次荧光造影证实动脉瘤夹闭满意,术后复查 CTA 和(或)DSA 证实术中荧光血管造影结果。随访40例患者(3~6个月)GOS 评分5分30例,4分7例,3分2例,2分1例。结论吲哚菁绿荧光血管造影对于术中判断动脉瘤夹闭情况、载瘤动脉及动脉瘤临近分支通畅情况有重要的参考价值,可提高手术安全性,从而有效改善患者预后。