外用糖皮质激素联合夫西地酸乳膏对婴儿湿疹的干预作用

摘要

Objective To investigate the clinical efficacy of topical corticosteroids combined with fusidic acid cream in treating infantile eczema.Methods Four hundreds cases of infantile eczema in the outpatient department of our hospital from March 2012 to January 2015 were collected and divided into observation group (220 cases) and control group (180 cases).The observation group received topical corticosteroids combined with fusidic acid cream,while the control group was treated only by topical corticosteroid.The medication time reaching to clinical cure,effect maintenance time during 30 d observation period and recurrence rate were recorded in the two groups.Results During the 30 days of observation, 50 cases of infantile eczema withdrew from the study,17 cases in the observation group and 33 cases in the control group.The average medication time in the observation group was (2.2±0.9)d,which was shorter than (3.2±1.1)d in the control group.The effect maintenance time during observation period in the observation group was (11.7±5.4) d,which was longer than (7.2±4.0)d in the control group,the difference was statistically significant(P<0.05);74.0% of recurrent cases during the observation period in the observation group manifested by mild eczema,while 57.8% in the control group manifested by mild eczema and had no need to use corticosteroid,the improvement of symptoms during recurrent period for the patients in the observation group was better than that for the patients in the control group,the difference was statistically significant (P<0.05).Conclusion Topical corticosteroids combined with fusidic acid cream for treating infantile eczema can reduce the medication time,prolong the effect maintenance time,and alleviate the recurrent symptoms.%目的 探讨外用糖皮质激素联合夫西地酸乳膏治疗婴儿湿疹的临床疗效.方法 收集2012年3月至2015年1月该院门诊收治的湿疹婴儿400例,将其分为观察组(220例)和对照组(180例),观察组接受外用糖皮质激素联合夫西地酸乳膏,对照组单纯外用糖皮质激素.随诊记录两组达到临床治愈所需的用药时间,以及观察期30 d内疗效维持时间及复发率.结果 30 d观察期内,共有50例婴儿退出本研究,其中观察组17例、对照组33例.观察组湿疹平均用药时间[(2.2±0.9)d]较对照组[(3.2±1.1)d]缩短,观察期内疗效维持时间[(11.7±5.4)d]较对照组[(7.2±4.0)d]延长,差异均有统计学意义(P<0.05);观察期内观察组中74.0%复发患儿表现为轻度湿疹,对照组57.8%复发患儿表现为轻度湿疹,后续无需使用糖皮质激素,观察组复发时症状改善情况优于对照组,差异有统计学意义(P<0.05).结论 外用糖皮质激素联合西地酸乳膏治疗婴儿湿疹可减少用药时间,延长疗效维持时间,减轻湿疹复发时的症状.