NQO1和NQO2的表达在卵巢癌临床预后中的作用

摘要

Objective To investigate the effect of quinone oxidoreductase 1 (NQO1) and quinone oxidoreductase 2 (NQO2) expression in the prognosis of ovarian carcinoma.Methods The two online databases were used to perform the online analysis on the NQO1 and NQO2 mRNA levels and prognosis of ovarian cancer patients,1 306 cases of ovarian cancer were performed the Kaplan-Meier analysis by using the KaplanMeier plotter (K-M plotter);578 cases of ovarian cancer in the TCGA database were performed the univariate COX regression survival analysis.Results The K-M plotter analysis showed that the NQO1 expression level had no obvious correlation with the prognosis of ovarian cancer (P>0.05),the higher the NQO2 level,the better the prognosis (HR=0.83,P=0.006 2).The COX regression survival analysis showed that the NQO1 expression level had no obvious correlation with the prognosis of ovarian cancer(P>0.05),the higher the NQO2 level,the better the prognosis (P=0.038 29).Conclusion NQO2 expression level has no obvious correlation with the prognosis of ovarian cancer,moreover the higher the NQO2 expression level,the better the clinical prognosis of ovarian cancer.%目的 探讨醌氧化还原酶1(NQO1)和醌氧化还原酶2(NQO2)表达水平在卵巢癌临床预后中的作用.方法 应用两个在线数据库对NQO1、NQO2 mRNA水平和卵巢癌患者预后进行在线分析,通过KaplanMeier plotter(K-M plotter)数据库对1 306例卵巢癌患者进行Kaplan-Meier分析;通过SurvExpress数据库对TCGA数据库中的578例卵巢癌患者进行单因素COX回归生存分析.结果 K-M plotter分析显示:在卵巢癌中NQO1表达水平与卵巢癌预后无明显相关性(P>0.05),NQO2的表达水平越高预后越好(HR=0.83,P=0.006 2).COX回归生存分析显示:在卵巢癌患者中NQO1的表达水平与卵巢癌预后无明显相关性(P>0.05),NQO2 mRNA水平越高预后越好(P=0.038 29).结论 NQO1的表达水平与卵巢癌预后并无明显相关性,而NQO2表达水平越高,卵巢癌临床预后越好.