阿维A联合白芍总苷治疗银屑病的Meta分析

摘要

目的 系统评价阿维A联合白芍总苷治疗银屑病的临床疗效及不良反应.方法 计算机检索Cochrane Library、PubMed和Embase等数据库,收集全部有关阿维A联合白芍总苷治疗银屑病的临床对照试验,其检索时间为建库到2016年10月.根据纳入标准提取资料及评价质量后,运用Cochrane协作网里的RevMan 5.3软件对纳入文献进行分析.结果 纳入8篇文献.Meta分析结果显示:阿维A联合白芍总苷治疗组的总有效率[OR=3.15,95％CI(2.04,4.86),P<0.01]和PASI评分改善[WMD=-2.05,95％CI(-2.74,-1.36),P<0.05]优于单纯阿维A;阿维A联合白芍总苷的口唇干裂、眼干、皮肤干燥及瘙痒、肝功能异常和血脂增高的发生率均低于单纯阿维A(P<0.05),但鼻出血发生率组间比较差异无统计学意义(P>0.05).结论 阿维A联合白芍总苷治疗银屑病能够提高临床疗效和降低不良反应.%Objective To evaluate the clinical efficacy and adverse reaction of acitretin combined with total glucosides of peony for patients with psoriasis.Methods Clinical controlled trials that compared acitretin with combination therapy of acitretin and total glucosides of peony for patients with psoriasis were searched in the Cochrane Library,PubMed,Embase and so on(from establishment to October 2016).All extractive data analysis was performed by Review Manage version 5.3 after the data was extracted and the quality was assessed according to the inclusion criteria.Results A total of 8 articles were included.The results of meta-analysis showed that the total effective rate[OR=3.15,95％CI(2.04,4.86),P<0.01] and the psoriasis area and severity index(PASI)score[WMD=-2.05,95％CI(-2.74,-1.36),P<0.05] of treatment group were better than those of control group.The incidence rates of cheilosis,dryness of eye,dryness and itch of skin,dysfunction of liver,and hyperlipemia in treatment group were lower than those in control group(P<0.05).However,the incidence of rhinorrhagia was no statistically significant difference between the two groups(P>0.05).Conclusion Acitretin combined with total glucosides of peony for patients with psoriasis can improve the clinical efficacy and reduce the incidence of adverse reaction.