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>Novel rAAV production system with low contamina-tion of helper virus
Novel rAAV production system with low contamina-tion of helper virus
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The Cre-loxP system was introduced in theproduction of recombinant AAV (rAAV). Defective adenovi-rus AdLC was used as the helper virus. While doing themass production of recombinant AAV carrying EGFP orhuman clotting factor Ⅸ (hFⅨ) gene, the generation ofhelper virus was significantly limited, it increased the sim-plicity of rAAV purification. The results from in vivo study demonstrated the superiority of this method. This systemprovides a novel approach for the application of rAAV sys-tem in gene therapy.
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机译:An Innovative Workflow for Appropriate Selection of Subsurface-Surface Model Integration Scheme Based on Petroleum Production System Nature, User Needs,and Integrated Simulation Performance