高血压靶器官损害患者高敏C反应蛋白和白细胞介素-6的变化及意义

摘要

Objective To investigate the changes of high sensitivity C-reactive protein (hs-CRP) and inter-leukin-6 (IL-6) in patients with hypertension and target organs damage (TOD), and to investigate its clinical signifi-cance. Methods The levels of hs-CRP and IL-6 in patients of the normal blood pressure group (n=100), simple hy-pertension group (n=100), hypertension and coronary heart disease group (n=100), and hypertension and cerebral in-farction group (n=100) were measured, respectively. Results There were no statistically significant differences in the distribution of age and gender between the four groups (P>0.05). There were statistically significant differences in the expression levels of hs-CRP and IL-6 between the hypertension and TOD group and the normal control group ( P0.05);高血压及靶器官损害组hs-CRP和IL-6水平与健康对照组相比差异有统计学意义(P<0.01),高血压合并冠心病组及高血压合并脑梗死组与高血压组比较差异有统计学意义(P<0.05).结论 hs-CRP和IL-6水平增高,对预测高血压靶器官损害的病情和预后有重要意义.