目的：评价采用克罗米芬（CC）及来曲唑（LE）分别配伍注射用尿促性素（HMG）治疗多囊卵巢综合征（PCOS）患者的疗效。方法选取本院生殖医学科门诊在2013年6月至2014年6月收治的99例PCOS患者，随机均分为CC＋HMG组（50例）和LE＋HMG组（49例）。比较2组间的临床效果，即单卵泡发育率，黄素化未破裂卵泡综合征（LUF）发生率、多卵泡排卵率、HCG日子宫内膜厚度、卵巢过度刺激综合征（OHSS）发生率、临床妊娠率，多胎妊娠率、异位妊娠率及早期流产率。结果患者经过3个疗程的治疗后LE＋HMG组患者单卵泡发育率、LUF率及OHSS发生率、早期流产率均低于CC＋HMG组，多卵泡排卵率高且均有统计学意义，2组间的HCG日子宫内膜厚度、临床妊娠、多胎妊娠及异位妊娠发生率差异均无统计学意义。结论采用LE＋HMG方案指导同房较CC＋HMG方案，患者的临床妊娠率虽差异无统计学意义，但能有效降低多卵泡发育率及LUF率，能降低临床并发症OHSS的发生且流产率低。%Objective To evaluate the effects of Clomiphene Citrate (CC) versus Letrozole (LE) combined with HMG in patients with polycystic ovary syndrome (PCOS). Methods Ninety-nine PCOS patients hospitalized in the Department of Reproductive Medicine of our hospital between June 2013 and June 2014 were randomly divided into CC+HMG group (n=50) and LE+HMG group (n=49). The clinical effects, including the single follicular development rate, luteinized unruptured follicle syndrome (LUFS) rate, multiple follicular ovulation rate, the endometrium thickness of human chorionic gonadotropin (HCG) day, the ovarian hyper-stimulation syndrome (OHSS) incidence rate, pregnan-cy rate, polytocous and ectopic pregnancy rate and early abortion rate, between the two groups were compared. Resluts After 3 courses of treatment, the single follicular development rate, LUF rate, OHSS incidence rate, and ear-ly abortion rate in the LE+HMG group were significantly lower than those of CC+HMG group, with statistical signifi-cance in multiple follicular ovulation rate, and no statistical differences in the endometrium thickness of HCG day and the incidences of clinical pregnancy, multiple pregnancy, and ectopic pregnancy. Conclusion Compared with the protocol of CC+HMG, LE+HMG can effectively decrease multiple follicular development rate and LUF rate, and de-crease the incidence of OHSS clinical complications with lower abortion rate. There is no statistical difference in the clinical pregnancy rate between the two protocols.
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