Objective To investigate the clinical effects of intravenous infusion and local arterial perfusion of mesenchymal stem cells (MSCs) on osteonecrosis of femoral head(ONFH) in patients with systemic lupus erythemato-sus(SLE). Methods Four SLE patients with ONFH were randomly included in the study. MSCs suspension was per-fused via percutaneous-femoral artery puncture and medial femoral circumflex artery, with intravenous infusion of MSCs. The second treatment was performed after the 2 weeks interval. The SLE disease activity, pain, walking dis-tance, joint function, MRI evaluation indicators at the baseline and at half a year after the treatment were evaluated. Results At the short-term follow-up (6 months), the pain and joint activity were improved in 4 cases, and the imag-ing findings were not improved in 1 case. At the end of long-term follow-up (3 years), 1 case of femoral head collapse was found in the study group. Conclusion MSCs infusion in the treatment of ONFH is safe, with noadverse reactions and high short-term effective rate. Long-term follow-up can reduce the incidence of femoral head collapse. Although this study is for small sample observation, more number of cases may be further expanded clinically. It can be used as a new technology widely.%目的：观察间充质干细胞（MSCs）全身输注联合局部介入治疗系统性红斑狼疮（SLE）患者股骨头缺血性坏死（ONFH）的临床疗效。方法选择4例SLE股骨头坏死患者，经皮-股动脉穿刺经旋股内动脉灌注MSCs悬液，同时静脉输注MSCs。间隔2周再进行第2次治疗。评估治疗前及治疗后半年SLE疾病活动性、疼痛、行走距离、关节功能、磁共振成像（MRI）评价等指标。结果短期随访（6个月），4例疼痛改善及关节活动度均改善，1例影像学无改善。随访终点（3年），治疗组4例中1例发生股骨头塌陷。结论 MSCs灌注治疗股骨头坏死安全，无不良反应，短期内有效率高，长期随访可降低股骨头塌陷发生率，本研究为小样本观察，临床可进一步扩大病例数，以期作为一种新技术进行广泛开展。
展开▼
