高血压前期患者血清网膜素-1及高敏C反应蛋白水平变化与早期肾损伤的临床相关性

摘要

目的 研究高血压前期患者血清网膜素-1(Omentin-1)水平与高敏C反应蛋白(hs-CRP)水平的变化情况,并以微量白蛋白/肌酐比值(UACR)为诊断指标,探究高血压前期是否存在早期肾损伤.方法 收集体检中心患者97例,根据血压水平分为高血压前期组(52例),健康对照组(45例).采用酶联免疫吸附法测定O-mentin-1及hs-CRP水平,采用散射比浊法检测尿微量白蛋白水平.结果 高血压前期组的Omentin-1水平显著低于健康对照组[(141±53)与(214±34)ng/mL](P<0.01),hs-CRP水平和UACR显著高于健康对照组[分别为(2.1±0.5)与(1.5±0.6)mg/L和(10±4)与(7±5)mg/g](P<0.01).多元线性回归分析显示,Omentin-1是影响UACR的主要因素且二者呈负相关.结论 高血压前期人群存在着Omentin-1及hs-CRP水平的异常变化,Omentin-1水平下降与早期肾损伤存在一定的内在关系.%Objective To determine the changes of serum omentin-1 and high-sensitivity C-reactive protein (hs-CRP) levels in patients with prehypertension, and to determine the presence of early renal damage in the prehy-pertension by using the urinary albumin creatinine ratio (UACR) as a diagnostic indicator. Methods Ninety-seven patients in the physical examination center were included in the study, and divided into the prehypertension group ( n=52) and healthy control group (n=45) according to blood pressure level. The levels of Omentin-1 and hs-CRP were measured by enzyme-linked immunosorbent assay (ELISA). Microalbuminuria level was determined by scatter tur-bidimetry. Results The Omentin-1 level in the prehypertension group was significantly lower than that in the healthy control group [(141±53) vs (214±34) ng/mL] (P<0.01), whereas the hs-CRP level and UACR were significantly higher than those in the healthy control group (2.1±0.5) vs (1.5±0.6) mg/L and (10±4) vs (7±5) mg/g] (P<0.01). Multiple lin-ear regression analysis showed that Omentin-1 was the main factor affecting UACR, and there was negative correlation between them. Conclusion There are abnormal changes of Omentin-1 and hs-CRP levels in patients with prehyper-tension, and there is a certain internal relationship between the decrease of Omentin-1 and early renal damage.