鞘氨醇-1-磷酸受体1在疼痛中的作用研究

摘要

鞘氨醇-1-磷酸受体1( sphingosine-1-phosphate receptor 1,S1PR1)属于G蛋白偶联受体,其能调节多种下游信号分子和细胞功能。研究发现S1PR1在疼痛中发挥重要作用,但激活S1PR1产生致痛作用还是镇痛作用尚存在争议。该文讨论了 S1P/S1PR1信号在疼痛研究中的最新观点与进展,以增进对其生物学功能及病理作用的了解。%Sphingosine-1-phosphate receptor 1(S1PR1) is a new member of G protein-coupled receptor family. A great body of data suggest S1PR1 is capable of regulating lots of downstream signaling molecules and cellular processes. It is found that S1P/S1PR1 plays an important role in the development and mainte-nance of pain. However, it is controversial whether activation of S1PR1 would enhance or attenuate pain. Here, recent studies and current perspectives are discussed in order to better under-stand the biological and pathological roles of S1PR1 in pain mod-ulation.