FOX家族介导的上皮间质转化在肿瘤转移中的研究进展

摘要

Epithelial mesenchymal transition ( EMT) is one of the important biological processes in tumor invasion and metastasis . However , due to the complexity of EMT signaling pathway and its unclear molecular mechanism , the treatment of EMT is still a worldwide problem .But many studies have proved that EMT is not an irreversible process .In recent years , the research of FOX gene family in EMT shows its important role in tumor metastasis . This review focuses on the FOX-mediated EMT process in many kinds of tumor , aiming to have a better understanding of EMT signaling network , and provide a new target for the effective pre-vention of EMT .%在肿瘤的侵袭转移进程中，上皮间质转化（ epithelial mesenchymal transition，EMT）是其中一个重要的生物学过程。但由于EMT复杂的信号通路和未尽阐明的分子机制，治疗EMT仍然是世界性的难题。但多种研究也证实了EMT并非是不可逆转的过程。近年来对叉头框转录因子（ FOX）基因家族在EMT中的研究，显示了其在肿瘤转移中具有重要的调控作用。该文综述了FOX基因家族介导的EMT过程在肿瘤多种生物学过程的研究，以期对EMT的信号网络有更好的了解，并为有效干预EMT提供新的依据。