miRNAs在甲基苯丙胺成瘾中的作用研究进展

摘要

甲基苯丙胺(methamphetamine,METH)成瘾是机体长期接触METH后,中枢神经系统在分子、细胞、神经环路功能和脑结构等层次发生的代偿性适应,该过程有多种途径和多种机制共同参与.miRNAs作为一种新型基因转录后调控分子和突触的调节因子,大量存在于中枢神经系统,对中枢神经系统具有重要的调控作用.研究表明,miRNAs在METH成瘾中发挥着重要的调控作用.该文对miRNAs在METH成瘾机制中的表达特征及调控作用进行综述,并将与METH成瘾相关的miRNAs分子以及各miRNAs分子在不同组织器官中的差异性表达部位进行归纳整理,为进一步研究miRNAs分子在METH成瘾中的作用及发现新的药物作用靶点提供参考.%The methamphetamine(METH)addiction is a compensatory adaptation of the central nervous system after the long-term exposure to METH in the molecular,cellular,neuronal loop function and brain structure.As a new type of post transcriptional regulatory molecules and regulatory factors,miRNAs are a large number of regulatory factors in the central nervous system.Studies have shown that miRNAs play an important role in the regulation of METH addiction.This paper is to review and summarize the expression features and the regulatory role of miRNAs in METH addiction,as well as the different expression of miRNAs in different tissues and organs.The aim of this paper is to provide a reference for further study on the role of miRNAs molecules in METH addiction and the discovery of new drug targets.