AIM:To study the chemical constituents of Isodon japonicus. METHOD: We isolated and elucidated the chemical constituents using chromatographic techniques and spectral analysis. RESULT and CONCLUSION:Twenty diterpenoids including three new ent-kauranoids (1-3) and a pair of epimers of new ent-abietanoid (4 and 5) were isolated and identified. These five new diterpenoids are 7β, 15β, 16β-trihydroxy-6β, 17-diacetoxy-7α, 20-epoxy-ent-kaurane (1) ,16(S)-6β,11α, 17-trihydroxy-6,20-epoxy- 1α, 7-olide-6,7-seco-ent-kaur-15-one (2), 11α-dihydroxy-1α-acetoxy-7,20-olide-6,7-seco-ent-kaur-16-en-15-one (3) , 15(S)-3α, 17, 18-trihydroxy-ent-abieta-7(8)-en-15,16-acetonide (4), 15(R)-3α,17,18-trihydroxy-ent-abieta- 7(8)-en-15,16-acetonide (5), and named maoyecrystals C-E, G and H, respectively. The13C NMR data of lasiokaurin (13) is reported in this paper for the first time.%目的:对河南产毛叶香茶菜化学成分进行研究.方法:运用各种色谱技术和波谱分析对其化学成分进行分离鉴定.结果:分离鉴定了20个二萜化合物.结论:化合物1-3为三个新的对映-贝壳杉烷二萜类化合物,结构分别为7β,15β,16β-三羟基-6β,17β-二乙酰氧基-7α,20-环氧-对映-贝壳杉烷(1)、16(S)-6β,11α,17β-三羟基-6,20-环氧-1α,7β-内酯-6,7-断裂-对映-贝壳杉-15酮(2)和6α,11α-二羟基-1α-乙酰氧基-7,20-内酯-6,7-断裂-对映-贝壳杉-16-烯-15-酮(3),依次命名为毛叶香茶菜丙素、丁素和戊素;化合物4和5为一对新化合物,其结构为3α,15α,1β6,17β,18β-五羟基-对映-松香-7(8)-烯的丙酮化物,其丙酮化缩合部分互为对映体,分别命名为毛叶香茶菜庚素(4)和辛素(5).
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